Literature summary for 6.1.1.4 extracted from

Wang, X.; Fonseca, B.D.; Tang, H.; Liu, R.; Elia, A.; Clemens, M.J.; Bommer, U.A.; Proud, C.G.
Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling (2008), J. Biol. Chem., 283, 30482-30492.

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Protein Variants

Protein Variants	Comment	Organism
additional information	using a Chinese hamster ovary cell line containing a temperature-sensitive mutation in leucyl-tRNA synthetase which is active at 34 °C but defective at 39.5 °C, it is shown that shifting the cells to the latter temperature mimics the effects of amino acid starvation on protein synthesis. Leucine deprivation markedly inhibits mTORC1 signaling in these cells, but shifting the cells to the nonpermissive temperature for the synthetase does not. These data indicate that uncharged tRNALeu does not switch off mTORC1 signaling and suggest that mTORC1 is controlled by a distinct pathway that senses the availability of amino acids	Cricetulus griseus

Organism

Organism	UniProt	Comment	Textmining
Cricetulus griseus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
CHO cell	-	Cricetulus griseus	-

Synonyms

Synonyms	Comment	Organism
Leucyl-tRNA synthetase	-	Cricetulus griseus

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Release 2023.1 (January 2023)