Literature summary for 6.1.1.3 extracted from

Cao, Z.; Wang, H.; Mao, X.; Luo, L.
Noncanonical function of threonyl-tRNA synthetase regulates vascular development in zebrafish (2016), Biochem. Biophys. Res. Commun., 473, 67-72 .

Search for more literature for 6.1.1.3

Cloned(Commentary)

Cloned (Comment)	Organism
gene tars, quantitative real-time PCR expression analysis	Danio rerio

Protein Variants

Protein Variants	Comment	Organism
Q502R	identification of the zebrafish cq16 mutant gene encoding threonyl-tRNA synthetase (tars) with a missense mutation. The abnormal branching of intersegmental vessels is caused by the increased expression of vascular endothelial growth factor A (vegfa) in tarscq16 mutant. Inhibition of Vegf signaling suppresses the abnormal vascular branching observed in tarscq16 mutant	Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	A2BIM7	-	-

Synonyms

Synonyms	Comment	Organism
TarS	-	Danio rerio
Threonyl-tRNA synthetase	-	Danio rerio

General Information

General Information	Comment	Organism
malfunction	identification of the zebrafish cq16 missense mutant Q502R presenting the disorganized vessels with abnormal branching of the established intersegmental vessels (ISVs) as well as aberrant patterning of the brain vascular network after 50 h post fertilization. The mutation in cq16 mutant gene encoding threonyl-tRNA synthetase (tars) is responsible for the phenotype. The abnormal branching of ISVs is caused by the increased expression of vascular endothelial growth factor A (vegfa) in tarscq16 mutant. Inhibition of Vegf signaling suppresses the abnormal vascular branching observed in tarscq16 mutant. The mutation in tars leads to ISV abundant sprouting in zebrafish. Injection of human TARS mRNA potently reduces the vascular aberrant branching in tarscq16 mutant	Danio rerio
physiological function	a conserved, noncanonical function of tars regulates vascular development presumably by modulating the expression of vascular endothelial growth factor A (vegfa). Vegf signaling stimulates endothelial cell migration and proliferation by activating Vegf receptor tyrosine kinases	Danio rerio

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Release 2023.1 (January 2023)