Literature summary for 6.1.1.26 extracted from

Englert, M.; Moses, S.; Hohn, M.; Ling, J.; ODonoghue, P.; Soell, D.
Aminoacylation of tRNA 2'- or 3'-hydroxyl by phosphoseryl- and pyrrolysyl-tRNA synthetases (2013), FEBS Lett., 587, 3360-3364.

Search for more literature for 6.1.1.26

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-pyrrolysine + tRNAPyl	Methanosarcina barkeri	the enzyme attaches attaches L-pyrrolysine only to tRNA transcripts with a 3'-OH group at A76, whereas no aminoacylation at the 2'-OH group is detected	AMP + diphosphate + L-pyrrolysyl-tRNAPyl	-	?
ATP + L-pyrrolysine + tRNAPyl	Desulfitobacterium hafniense	the enzyme attaches L-pyrrolysine only to tRNA transcripts with a 3'-OH group at A76, whereas no aminoacylation at the 2'-OH group is detected	AMP + diphosphate + L-pyrrolysyl-tRNAPyl	-	?

Organism

Organism	UniProt	Comment	Textmining
Desulfitobacterium hafniense	-	-	-
Methanosarcina barkeri	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-pyrrolysine + tRNAPyl	the enzyme attaches attaches L-pyrrolysine only to tRNA transcripts with a 3'-OH group at A76, whereas no aminoacylation at the 2'-OH group is detected	Methanosarcina barkeri	AMP + diphosphate + L-pyrrolysyl-tRNAPyl	-	?
ATP + L-pyrrolysine + tRNAPyl	the enzyme attaches L-pyrrolysine only to tRNA transcripts with a 3'-OH group at A76, whereas no aminoacylation at the 2'-OH group is detected	Desulfitobacterium hafniense	AMP + diphosphate + L-pyrrolysyl-tRNAPyl	-	?

Synonyms

Synonyms	Comment	Organism
PylRS	-	Methanosarcina barkeri
PylRS	-	Desulfitobacterium hafniense
pyrrolysyl-tRNA synthetase	-	Methanosarcina barkeri
pyrrolysyl-tRNA synthetase	-	Desulfitobacterium hafniense

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Methanosarcina barkeri
ATP	-	Desulfitobacterium hafniense

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Release 2023.1 (January 2023)