Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.20 extracted from

  • Fishman, R.; Ankilova, V.; Moor, N.; Safro, M.
    Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese (2001), Acta Crystallogr. Sect. D, 57, 1534-1544.
    View publication on PubMed
Search for more literature for 6.1.1.20

Crystallization (Commentary)

Crystallization (Comment) Organism
native enzyme complexed with phenylalanyl-adenylate in presence of manganese, X-ray diffraction structure determination at 2.6 A resolution and analysis Thermus thermophilus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ not bound to the active site, located at the interface of alpha and beta subunits Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-phenylalanine + tRNAPhe Thermus thermophilus
-
 AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
 class II enzyme
-

Reaction

Reaction Comment Organism Reaction ID
ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe reaction mechanism Thermus thermophilus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-phenylalanine + tRNAPhe
-
 Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?
ATP + L-phenylalanine + tRNAPhe two-step reaction, the first step, formation of phenylalanyl-adenylate intermediate, proceeds also within crystals, where the intermediate is bound to the active site involving neighbouring residues Phe258 and Phe260 Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?
additional information the enzyme probably interacts with DNA Thermus thermophilus ?
-
 ?

Synonyms

Synonyms Comment Organism
CML33
-
 Thermus thermophilus
FRS
-
 Thermus thermophilus
HSPC173
-
 Thermus thermophilus
L-Phenylalanyl-tRNA synthetase
-
 Thermus thermophilus
Phenylalanine translase
-
 Thermus thermophilus
Phenylalanine--tRNA ligase
-
 Thermus thermophilus
Phenylalanine-tRNA synthetase
-
 Thermus thermophilus
Phenylalanyl transfer ribonucleic acid synthetase
-
 Thermus thermophilus
Phenylalanyl-transfer ribonucleate synthetase
-
 Thermus thermophilus
Phenylalanyl-transfer RNA ligase
-
 Thermus thermophilus
Phenylalanyl-transfer RNA synthetase
-
 Thermus thermophilus
Phenylalanyl-tRNA ligase
-
 Thermus thermophilus
Phenylalanyl-tRNA synthetase
-
 Thermus thermophilus
PheRS
-
 Thermus thermophilus
Synthetase, phenylalanyl-transfer ribonucleate
-
 Thermus thermophilus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Thermus thermophilus