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Literature summary for 6.1.1.2 extracted from

  • Ewalt, K.L.; Schimmel, P.
    Activation of angiogenic signaling pathways by two human tRNA synthetases (2002), Biochemistry, 41, 13344-13349.
    View publication on PubMed
Search for more literature for 6.1.1.2

Activating Compound

Activating Compound Comment Organism Structure
interferon gamma strong upregulation of the alternatively spliced truncated mini enzyme form Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-tryptophan + tRNATrp Homo sapiens enzyme contributes to biological processes involving cell signaling such as angiogenesis regulation AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?
additional information Homo sapiens the enzymes C-terminal domain, an EMAP II-like protein, inhibits angiogenesis signaling pathways and the development of blood vessels ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification regulated mechanism, the C-terminal domain of the enzyme, which has anti-angiogenic activity and inhibits immune cells, is isolated by proteolytic cleavage or alternative splicing, the mini enzyme is a potent inhibitor of blood vessel development, the full-length enzyme is inactive, enzyme N-terminally processed by elastase, resulting in 2 different forms T1 and T2, has also anti-angiogenic activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
endothelium umbilical vein Homo sapiens
-
lung
-
 Homo sapiens
-
additional information tissue-specific gen expression Homo sapiens
-
placenta
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
testis
-
 Homo sapiens
-
trachea
-
 Homo sapiens
-
umbilical vein endothelial cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-tryptophan + tRNATrp
-
 Homo sapiens AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?
ATP + L-tryptophan + tRNATrp enzyme contributes to biological processes involving cell signaling such as angiogenesis regulation Homo sapiens AMP + diphosphate + L-tryptophan-tRNATrp
-
 ?
additional information the enzymes C-terminal domain, an EMAP II-like protein, inhibits angiogenesis signaling pathways and the development of blood vessels Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TrpRS
-
 Homo sapiens
Tryptophanyl-tRNA synthase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens