Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.19 extracted from

  • Jain, V.; Yogavel, M.; Sharma, A.
    Dimerization of arginyl-tRNA synthetase by free heme drives its inactivation in Plasmodium falciparum (2016), Structure, 24, 1476-1487 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
hemin hemin induces a dimeric form of the enzyme that is thus rendered enzymatically dead as it is unable to recognize its cognate tRNAarg Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Plasmodium falciparum 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
69000
-
blue native PAGE Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-arginine + tRNAArg Plasmodium falciparum
-
AMP + diphosphate + L-arginyl-tRNAArg
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q8I5M2
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity column chromatography, ion-exchange column chromatography, and Superdex 200 gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-arginine + tRNAArg
-
Plasmodium falciparum AMP + diphosphate + L-arginyl-tRNAArg
-
?

Subunits

Subunits Comment Organism
monomer 1 * 69000, SDS-PAGE Plasmodium falciparum

Synonyms

Synonyms Comment Organism
Arginyl-tRNA synthetase
-
Plasmodium falciparum
RRS
-
Plasmodium falciparum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
43
-
melting temperature Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
ATP
-
Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
pH and temperature not specified in the publication Plasmodium falciparum hemin