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Literature summary for 6.1.1.18 extracted from

  • Kim, T.; Park, S.G.; Kim, J.E.; Seol, W.; Ko, Y.G.; Kim, S.
    Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex (2000), J. Biol. Chem., 275, 21768-21772.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of various Myc-tagged enzyme mutants in human embryonic kidney 293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a deletion mutant comprising only the C-terminal catalytic domain is targeted into the multienzyme complex, while a deletion mutant comprising only the N-terminal domain is not Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamine + tRNAGln Homo sapiens
-
AMP + diphosphate + L-glutaminyl-tRNAGln
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
enzyme forms a macromolecular protein complex
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamine + tRNAGln
-
Homo sapiens AMP + diphosphate + L-glutaminyl-tRNAGln
-
?
ATP + L-glutamine + tRNAGln tRNA substrate from bovine liver Homo sapiens AMP + diphosphate + L-glutaminyl-tRNAGln
-
?

Subunits

Subunits Comment Organism
More targeting into the multienzyme complex is mediated by the C-terminal catalytic domain Homo sapiens

Synonyms

Synonyms Comment Organism
Glutaminyl-tRNA synthetase
-
Homo sapiens
QRS
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens