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Literature summary for 6.1.1.16 extracted from

  • Mohana Parvatha Varddhini, S.; Sankaranarayanan, R.; Udayakumar, M.; Thamotharan, S.
    Identification of potential inhibitors of cysteinyl tRNA synthetase from Mycobacterium leprae TN strain through in silico virtual screening (2015), Res. J. Pharm. Biol. Chem. Sci., 6, 1737-1743 .
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
BTB13069 i.e. 5-methyl-2,4-diphenyl-1,2,3,4,5,6-hexahydrobenzo[b]pyrimido[4,5h][1,6]naphthyridine-1,3,6-trione Mycobacterium leprae
CD10929 i.e. 5-[5-(2,4-difluorophenyl)furan-2-yl]-1-(2,4-difluorophenyl)sulfonylpyrazole Mycobacterium leprae
CD12049 i.e. N2-phenyl-5-(1,3-dibenzylhexahydropyrimidin-5-yl)-2H-1,2,3,4-tetraazole-2-carbox amide Mycobacterium leprae
clofazimine i.e. N-5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine Mycobacterium leprae
dapsone i.e. diaphenylsulfone Mycobacterium leprae
DSSH00248 i.e. N1,N2-di[1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl]phthalamide Mycobacterium leprae
HTS01959 i.e. N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)-9-oxo-9H-fluorene-4carboxamide Mycobacterium leprae
HTS08262 i.e. [2-(2,3-dihydro-1-benzofuran-5-yl)-1,3-thiazol-4-yl] [4-(9H-fluoren-9-yl)piperazino] methanone Mycobacterium leprae
HTS11201 i.e. 7-[(3,4-dichlorophenyl)methyl]-1,3-dimethyl-8-[2-(2-oxoindol-3-yl)hydrazinyl]purine-2,6-dione Mycobacterium leprae
HTS11989 i.e. 1-[2-[3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]-5-(4-pyridinyl)-1,3,4-oxadiazole-3(2H)-yl]-1-ethanone Mycobacterium leprae
HTS12673 i.e. 1-[3-(4-methoxyphenyl)-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl]-2-{[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl] sulfanyl}-1-ethanone Mycobacterium leprae
NRB00567 i.e. 1-(9,10-dioxoanthracen-1-yl)sulfanylanthracene-9,10-dione Mycobacterium leprae
NRB04869 i.e. 7-(3-nitrophenyl)-6H,7H,8H-chromeno[3',4':5,6]pyrano[3,2-c]chromene-6,8-dione Mycobacterium leprae
PD00399 i.e. 2-[[1-benzothiophen-3-ylmethyl-[(1,3-dioxoisoindol-2-yl)methyl]amino]methyl]isoindole-1,3-dione Mycobacterium leprae
RF00088 i.e. 2-(5,7-dimethyl-4-oxochromen-3-yl)benzo[g]quinolone-4-carboxylic acid Mycobacterium leprae
rifampicin i.e. (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(1E)-[(4-methylpiperazin-1-yl)imino]methyl]-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate Mycobacterium leprae
RJC02308 i.e. 2-isoquinolin-3-yl-2-(1-nitro-9,10-dioxoanthracen-2-yl)acetonitrile Mycobacterium leprae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-cysteine + tRNACys Mycobacterium leprae
-
AMP + diphosphate + L-cysteinyl-tRNACys
-
?
ATP + L-cysteine + tRNACys Mycobacterium leprae TN
-
AMP + diphosphate + L-cysteinyl-tRNACys
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium leprae P57990
-
-
Mycobacterium leprae TN P57990
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-cysteine + tRNACys
-
Mycobacterium leprae AMP + diphosphate + L-cysteinyl-tRNACys
-
?
ATP + L-cysteine + tRNACys
-
Mycobacterium leprae TN AMP + diphosphate + L-cysteinyl-tRNACys
-
?

Synonyms

Synonyms Comment Organism
CysRS
-
Mycobacterium leprae
cysteinyl tRNA synthetase
-
Mycobacterium leprae

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mycobacterium leprae