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Literature summary for 6.1.1.16 extracted from
- Circular dichroism and fluorescence spectroscopy of cysteinyl-tRNA synthetase from Halobacterium salinarum ssp. NRC-1 demonstrates that group I cations are particularly effective in providing structure and stability to this halophilic protein (2014), PLoS ONE, 9, e89452 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Halobacterium salinarum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KCl | the enzyme loses half of its activity at KCl concentrations below 2 M | Halobacterium salinarum |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | required | Halobacterium salinarum | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-cysteine + tRNACys | Halobacterium salinarum | - |
AMP + diphosphate + L-cysteinyl-tRNACys | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Halobacterium salinarum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| HisTrap HP nickel-affinity column chromatography | Halobacterium salinarum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-cysteine + tRNACys | - |
Halobacterium salinarum | AMP + diphosphate + L-cysteinyl-tRNACys | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CysRS | - |
Halobacterium salinarum |
| Cysteinyl-tRNA synthetase | - |
Halobacterium salinarum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Halobacterium salinarum | |
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Release 2023.1 (January 2023)
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