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Literature summary for 6.1.1.16 extracted from

  • Akaike, T.; Ida, T.; Wei, F.Y.; Nishida, M.; Kumagai, Y.; Alam, M.M.; Ihara, H.; Sawa, T.; Matsunaga, T.; Kasamatsu, S.; Nishimura, A.; Morita, M.; Tomizawa, K.; Nishimura, A.; Watanabe, S.; Inaba, K.; Shima, H.; Tanuma, N.; Jung, M.; Fujii, S.; Watanabe, Y.; Ohmuraya, M.; Nagy, P.; Feelisch, M.; Fukuto,
    Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics (2017), Nat. Commun., 8, 1177 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.16

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-cysteine + tRNACys Mus musculus
-
 AMP + diphosphate + L-cysteinyl-tRNACys
-
 ?
ATP + L-cysteine + tRNACys Escherichia coli
-
 AMP + diphosphate + L-cysteinyl-tRNACys
-
 ?
ATP + L-cysteine + tRNACys Homo sapiens
-
 AMP + diphosphate + L-cysteinyl-tRNACys
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Mus musculus
Ni-NTA agarose column chromatography Escherichia coli
Ni-NTA agarose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-cysteine + tRNACys
-
 Mus musculus AMP + diphosphate + L-cysteinyl-tRNACys
-
 ?
ATP + L-cysteine + tRNACys
-
 Escherichia coli AMP + diphosphate + L-cysteinyl-tRNACys
-
 ?
ATP + L-cysteine + tRNACys
-
 Homo sapiens AMP + diphosphate + L-cysteinyl-tRNACys
-
 ?

Subunits

Subunits Comment Organism
? x * 70000, SDS-PAGE Homo sapiens
? x * 50000, SDS-PAGE Mus musculus
? x * 50000, SDS-PAGE Escherichia coli

Synonyms

Synonyms Comment Organism
CarS
-
 Escherichia coli
CARS1 isoform Homo sapiens
CARS2 isoform Mus musculus
Cysteinyl-tRNA synthetase
-
 Mus musculus
Cysteinyl-tRNA synthetase
-
 Escherichia coli
Cysteinyl-tRNA synthetase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Escherichia coli
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme plays a crucial role in endogenous cysteine hydropersulfide production and serves as the principal cysteine persulfide synthase in vivo Mus musculus
metabolism the enzyme plays a crucial role in endogenous cysteine hydropersulfide production and serves as the principal cysteine persulfide synthase in vivo Escherichia coli
metabolism the enzyme plays a crucial role in endogenous cysteine hydropersulfide production and serves as the principal cysteine persulfide synthase in vivo Homo sapiens