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Literature summary for 6.1.1.15 extracted from
- Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex (2000), J. Biol. Chem., 275, 31559-31562.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus | Cricetulus griseus | 5737 | - |
| nucleus | 2.9% of total activity in the cell, enzyme participates in a large and stable multienzyme complex | Cricetulus griseus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-proline + tRNAPro | Cricetulus griseus | the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm | AMP + diphosphate + L-prolyl-tRNAPro | - |
? |  |
| additional information | Cricetulus griseus | aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovary | cell line CRL-1781 | Cricetulus griseus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Cricetulus griseus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-proline + tRNAPro | - |
Cricetulus griseus | AMP + diphosphate + L-prolyl-tRNAPro | - |
? | |
| ATP + L-proline + tRNAPro | the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm | Cricetulus griseus | AMP + diphosphate + L-prolyl-tRNAPro | - |
? | |
| additional information | aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I | Cricetulus griseus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Global RNA synthesis factor | - |
Cricetulus griseus |
| Pro-tRNA synthetase | - |
Cricetulus griseus |
| Proline translase | - |
Cricetulus griseus |
| Proline--tRNA ligase | - |
Cricetulus griseus |
| Prolyl RNA synthetase | - |
Cricetulus griseus |
| Prolyl-transfer ribonucleate synthetase | - |
Cricetulus griseus |
| Prolyl-transfer ribonucleic acid synthetase | - |
Cricetulus griseus |
| Prolyl-transfer RNA synthetase | - |
Cricetulus griseus |
| Prolyl-tRNA synthetase | - |
Cricetulus griseus |
| ProRS | - |
Cricetulus griseus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Cricetulus griseus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Cricetulus griseus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Cricetulus griseus | |
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Release 2023.1 (January 2023)
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