Crystallization (Comment) | Organism |
---|---|
X-ray diffraction structure determination at 2.43-2.85 A of crystals formed by the free enzyme or the enzyme complexed with tRNAPro | Thermus thermophilus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | enzyme contains a unique additional zinc-binding domain | Thermus thermophilus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-proline + tRNAPro | Thermus thermophilus | - |
AMP + diphosphate + L-prolyl-tRNAPro | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermus thermophilus | - |
class IIa synthetase of the eukaryote/archaeon-like structure type | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro | the C-terminal extremity folds back into the active site | Thermus thermophilus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-proline + tRNAPro | - |
Thermus thermophilus | AMP + diphosphate + L-prolyl-tRNAPro | - |
? | |
ATP + L-proline + tRNAPro | initial docking state of the tRNAPro in which the anticodon stem-loop is engaged, particularly via the tRNAPro-specific bases G35 and G36, but the 3'-end does not enter the active site | Thermus thermophilus | AMP + diphosphate + L-prolyl-tRNAPro | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Global RNA synthesis factor | - |
Thermus thermophilus |
Pro-tRNA synthetase | - |
Thermus thermophilus |
Proline translase | - |
Thermus thermophilus |
Proline--tRNA ligase | - |
Thermus thermophilus |
Prolyl RNA synthetase | - |
Thermus thermophilus |
Prolyl-transfer ribonucleate synthetase | - |
Thermus thermophilus |
Prolyl-transfer ribonucleic acid synthetase | - |
Thermus thermophilus |
Prolyl-transfer RNA synthetase | - |
Thermus thermophilus |
Prolyl-tRNA synthetase | - |
Thermus thermophilus |
ProRS | - |
Thermus thermophilus |
ProRSTT | - |
Thermus thermophilus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Thermus thermophilus |