Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + glycine + tRNAGly | Homo sapiens | - |
AMP + diphosphate + glycyl-tRNAGly | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P41250 | - |
- |
Purification (Comment) | Organism |
---|---|
glutathione Sepharose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + glycine + tRNAGly | - |
Homo sapiens | AMP + diphosphate + glycyl-tRNAGly | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 75000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Glycyl-tRNA synthetase | - |
Homo sapiens |
GlyRS | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown decreases the global level of neddylation and causes cell cycle abnormality | Homo sapiens |
metabolism | the essential enzyme for protein synthesis also plays a critical role in neddylation by specifically binding to NEDD8 and enhancing neddylation. The enzyme preferentially binds and protects Ubc12N8 and E, and regulates cell cycle progression | Homo sapiens |