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Literature summary for 6.1.1.13 extracted from

  • Reusch, V.M.; Neuhaus, F.C.
    D-Alanine:membrane acceptor ligase from Lactobacillus casei (1971), J. Biol. Chem., 246, 6136-6143.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
Lacticaseibacillus casei
D-2-Amino-n-butyric acid hydroxamate
-
Lacticaseibacillus casei
D-Ser
-
Lacticaseibacillus casei
DL-2-Amino-n-butyric acid hydroxamate
-
Lacticaseibacillus casei
DL-Alanine amide
-
Lacticaseibacillus casei
DL-Alanine hydroxamate
-
Lacticaseibacillus casei
KCl
-
Lacticaseibacillus casei
additional information not inhibitory are D-Ala, L-Ala, L-2-amino-n-butyric acid, Gly, D-Thr, D-Ile, L-Ile, D-cycloserine, L-cycloserine, DL-alaniol Lacticaseibacillus casei
NaCl
-
Lacticaseibacillus casei
Ni2+
-
Lacticaseibacillus casei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
D-Ala
-
Lacticaseibacillus casei
0.85
-
D-2-amino-n-butyric acid
-
Lacticaseibacillus casei
3.3
-
ATP
-
Lacticaseibacillus casei

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Lacticaseibacillus casei 16020
-
soluble
-
Lacticaseibacillus casei
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ Ba2+ can replace Mg2+ in activity enhancement Lacticaseibacillus casei
Ca2+ Ca2+ can replace Mg2+ in activity enhancement Lacticaseibacillus casei
Co2+ Co2+ can replace Mg2+ in activity enhancement Lacticaseibacillus casei
K+ K+ can replace Mg2+ in activity enhancement Lacticaseibacillus casei
Mg2+ enhancement of activity, Mg2+ can be replaced by Ba2+, Ca2+, Co2+, K+, Na+ Lacticaseibacillus casei
Na+ Na+ can replace Mg2+ in activity enhancement Lacticaseibacillus casei

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
gel filtration Lacticaseibacillus casei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Alanine + ATP + ? Lacticaseibacillus casei biosynthesis of teichoic acid ?
-
?

Organism

Organism UniProt Comment Textmining
Lacticaseibacillus casei
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Lacticaseibacillus casei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-2-amino-n-butyric acid + membrane fragments not L-2-amino-n-butyric acid Lacticaseibacillus casei D-2-Amino-n-butryl-membrane fragments + AMP + diphosphate
-
?
ATP + D-Ala + membrane fragments ATP can be substituted by ADP, GTP, CTP, UTP, not by AMP, D-Ala cannot be substituted by L-Ala Lacticaseibacillus casei D-Alanyl-membrane fragments + AMP + diphosphate
-
?
D-Alanine + ATP + ? biosynthesis of teichoic acid Lacticaseibacillus casei ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 7
-
Lacticaseibacillus casei