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Literature summary for 6.1.1.11 extracted from

  • Yokogawa, T.; Shimada, N.; Takeuchi, N.; Benkowski, L.; Suzuki, T.; Omori, A.; Ueda, T.; Nishikawa, K.; Spremulli, L.L.; Watanabe, K.
    Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase (2000), J. Biol. Chem., 275, 19913-19920.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis Bos taurus
DNA and amino acid sequence determination and analysis Mus musculus
DNA and amino acid sequence determination and analysis, chromosomal localization at 19q13.1 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.22
-
tRNASerUGA pH 8.5, 37°C Bos taurus
0.37
-
tRNASerGCU pH 8.5, 37°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial isozyme Bos taurus 5739
-
mitochondrion mitochondrial isozyme Homo sapiens 5739
-
mitochondrion mitochondrial isozyme Mus musculus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
2 * 53000, alpha2, SDS-PAGE Bos taurus
100000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-serine + tRNASer Bos taurus
-
AMP + diphosphate + L-seryl-tRNASer
-
?
ATP + L-serine + tRNASer Homo sapiens
-
AMP + diphosphate + L-seryl-tRNASer
-
?
ATP + L-serine + tRNASer Mus musculus
-
AMP + diphosphate + L-seryl-tRNASer
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus Q9N0F3
-
-
Homo sapiens Q9NP81
-
-
Mus musculus Q9JJL8
-
-

Purification (Commentary)

Purification (Comment) Organism
2400fold from liver, mitochondrial isozyme Bos taurus

Reaction

Reaction Comment Organism Reaction ID
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer the tRNA recognition mechanism of mammalian mitochondrial enzyme differs considerably from that of its prokaryotic counterpart Homo sapiens
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer the tRNA recognition mechanism of mammalian mitochondrial enzyme differs considerably from that of its prokaryotic counterpart Mus musculus
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer the tRNA recognition mechanism of mammalian mitochondrial enzymediffers considerably from that of its prokaryotic counterpart Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0068
-
purified mitochondrial isozyme Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-serine + tRNASer
-
Bos taurus AMP + diphosphate + L-seryl-tRNASer
-
?
ATP + L-serine + tRNASer
-
Homo sapiens AMP + diphosphate + L-seryl-tRNASer
-
?
ATP + L-serine + tRNASer
-
Mus musculus AMP + diphosphate + L-seryl-tRNASer
-
?
ATP + L-serine + tRNASerGCU GCU for codon AGY, unusual tRNASer substrate, the mitochondrial isozyme aminoacylates both mitochondrial tRNASer types, the first corresponding to the codon AGY lacking the entire D arm Bos taurus AMP + diphosphate + L-seryl-tRNASerGCU
-
?
ATP + L-serine + tRNASerUGA UGA for codon UCN, unusual tRNASer substrate, the mitochondrial isozyme aminoacylates both mitochondrial tRNASer types, the second corresponding to the codon UCN with a different cloverleaf structure Bos taurus AMP + diphosphate + L-seryl-tRNASerUGA
-
?

Subunits

Subunits Comment Organism
dimer 2 * 53000, alpha2, SDS-PAGE Bos taurus

Synonyms

Synonyms Comment Organism
62 kDa RNA-binding protein
-
Bos taurus
62 kDa RNA-binding protein
-
Homo sapiens
62 kDa RNA-binding protein
-
Mus musculus
Serine transfer RNA synthetase
-
Bos taurus
Serine transfer RNA synthetase
-
Homo sapiens
Serine transfer RNA synthetase
-
Mus musculus
Serine translase
-
Bos taurus
Serine translase
-
Homo sapiens
Serine translase
-
Mus musculus
Serine--tRNA ligase
-
Bos taurus
Serine--tRNA ligase
-
Homo sapiens
Serine--tRNA ligase
-
Mus musculus
SerRS
-
Bos taurus
SerRS
-
Homo sapiens
SerRS
-
Mus musculus
SerRSmt
-
Bos taurus
SerRSmt
-
Homo sapiens
SerRSmt
-
Mus musculus
SERSEC
-
Bos taurus
SERSEC
-
Homo sapiens
SERSEC
-
Mus musculus
Seryl-transfer ribonucleate synthetase
-
Bos taurus
Seryl-transfer ribonucleate synthetase
-
Homo sapiens
Seryl-transfer ribonucleate synthetase
-
Mus musculus
Seryl-transfer ribonucleic acid synthetase
-
Bos taurus
Seryl-transfer ribonucleic acid synthetase
-
Homo sapiens
Seryl-transfer ribonucleic acid synthetase
-
Mus musculus
Seryl-transfer RNA synthetase
-
Bos taurus
Seryl-transfer RNA synthetase
-
Homo sapiens
Seryl-transfer RNA synthetase
-
Mus musculus
Seryl-tRNA synthetase
-
Bos taurus
Seryl-tRNA synthetase
-
Homo sapiens
Seryl-tRNA synthetase
-
Mus musculus
Synthetase, seryl-transfer ribonucleate
-
Bos taurus
Synthetase, seryl-transfer ribonucleate
-
Homo sapiens
Synthetase, seryl-transfer ribonucleate
-
Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.35
-
tRNASerGCU pH 8.5, 37°C Bos taurus
0.63
-
tRNASerUGA pH 8.5, 37°C Bos taurus
6.08
-
tRNASerUGA pH 8.5, 37°C Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Bos taurus
ATP
-
Homo sapiens
ATP
-
Mus musculus