Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of any but the anticodon domain of tRNASer and tRNASec causes a dramatic loss of serine acceptance | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00054 | - |
tRNASer | pH 7.6, 37°C | Homo sapiens | |
0.0011 | - |
tRNASer mutant without anticodon arm | pH 7.6, 37°C | Homo sapiens | |
0.0033 | - |
tRNASec | pH 7.6, 37°C | Homo sapiens | |
0.004 | - |
tRNASec mutant without anticodon arm | pH 7.6, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-serine + tRNASer | Homo sapiens | - |
AMP + diphosphate + L-seryl-tRNASer | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
class II enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
wild-type and mutant tRNA substrates, relative activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-serine + tRNASec | selenocysteine-incorporating tRNA wild-type and deletion mutants, secondary structures | Homo sapiens | AMP + diphosphate + L-seryl-tRNASec | - |
? | |
ATP + L-serine + tRNASec mutant without anticodon arm | - |
Homo sapiens | ? | - |
? | |
ATP + L-serine + tRNASer | - |
Homo sapiens | AMP + diphosphate + L-seryl-tRNASer | - |
? | |
ATP + L-serine + tRNASer | 4 isoacceptors of tRNASer, and tRNASer deletion mutants, secondary structures, the anticodon arms D and T are not involved in tRNA substrate recognition by the enzyme, only in formation of the L-shaped tRNA structure | Homo sapiens | AMP + diphosphate + L-seryl-tRNASer | - |
? | |
ATP + L-serine + tRNASer mutant without anticodon arm | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
62 kDa RNA-binding protein | - |
Homo sapiens |
Serine transfer RNA synthetase | - |
Homo sapiens |
Serine translase | - |
Homo sapiens |
Serine--tRNA ligase | - |
Homo sapiens |
SerRS | - |
Homo sapiens |
SerRSmt | - |
Homo sapiens |
SERSEC | - |
Homo sapiens |
Seryl-transfer ribonucleate synthetase | - |
Homo sapiens |
Seryl-transfer ribonucleic acid synthetase | - |
Homo sapiens |
Seryl-transfer RNA synthetase | - |
Homo sapiens |
Seryl-tRNA synthetase | - |
Homo sapiens |
Synthetase, seryl-transfer ribonucleate | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
tRNASec mutant without anticodon arm | pH 7.6, 37°C | Homo sapiens | |
0.007 | - |
tRNASec | pH 7.6, 37°C | Homo sapiens | |
0.023 | - |
tRNASer mutant without anticodon arm | pH 7.6, 37°C | Homo sapiens | |
0.062 | - |
tRNASer | pH 7.6, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |