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Literature summary for 6.1.1.10 extracted from

  • van Meel, E.; Wegner, D.J.; Cliften, P.; Willing, M.C.; White, F.V.; Kornfeld, S.; Cole, F.S.
    Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype (2013), BMC Med. Genet., 14, 106.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.10

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
F370L the mutant has 18% of wild type activity Homo sapiens
I523T the mutant has 16% of wild type activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 x * 100000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Homo sapiens
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56192
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
 Homo sapiens AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Subunits

Subunits Comment Organism
? x * 100000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MARS
-
 Homo sapiens
methionyl-tRNA synthetase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens