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Literature summary for 6.1.1.10 extracted from

  • Ochsner, U.A.; Bell, S.J.; OLeary, A.L.; Hoang, T.; Stone, K.C.; Young, C.L.; Critchley, I.A.; Janjic, N.
    Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model (2009), J. Antimicrob. Chemother., 63, 964-971.
    View publication on PubMed

Application

Application Comment Organism
medicine REP3123 is a fully synthetic methionyl-tRNA synthase inhibitor in pre-clinical development as a novel agent to treat Clostridium difficile infection, CDI Clostridioides difficile

Inhibitors

Inhibitors Comment Organism Structure
REP3123
-
Clostridioides difficile

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Clostridioides difficile
-
AMP + diphosphate + L-methionyl-tRNAMet
-
?

Organism

Organism UniProt Comment Textmining
Clostridioides difficile
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
Clostridioides difficile AMP + diphosphate + L-methionyl-tRNAMet
-
?

Synonyms

Synonyms Comment Organism
methionyl-tRNA synthetase
-
Clostridioides difficile
MetRS
-
Clostridioides difficile

Cofactor

Cofactor Comment Organism Structure
ATP
-
Clostridioides difficile