Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.10 extracted from

  • Ko, Y.G.; Kang, Y.S.; Kim, E.K.; Park, S.G.; Kim, S.
    Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis (2000), J. Cell Biol., 149, 567-574.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
polymerase I required by the nucleolar located enzyme Homo sapiens
rRNA required by the nucleolar located enzyme Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis, expression in Escherichia coli BL21(DE3) of the wild-type enzyme as His-tagged enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
actinomycin D inhibits the nucleolar located enzyme due to dependence on polymerase I Homo sapiens
alpha-Amanitin inhibits the nucleolar located enzyme due to dependence on polymerase I Homo sapiens
cisplatin inhibits the nucleolar located enzyme due to dependence on polymerase I Homo sapiens
RNase inhibits the nucleolar located enzyme due to dependence on rRNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
additional information no enzyme in quiescent cells Homo sapiens
-
-
nucleolus translocation from the cytoplasm is triggered by insulin, epidermal growth factor, translocation by a proliferation signal, the enzyme is part of the multi-aminoacyl-tRNA synthetase complex in the nucleolus Homo sapiens 5730
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Homo sapiens the nucleolar located enzyme is related to rRNA synthesis, the cytoplasmic enzyme is involved in protein biosynthesis AMP + diphosphate + L-methionyl-tRNAMet
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast of foreskin Homo sapiens
-
HeLa cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
Homo sapiens AMP + diphosphate + L-methionyl-tRNAMet
-
?
ATP + L-methionine + tRNAMet the nucleolar located enzyme is related to rRNA synthesis, the cytoplasmic enzyme is involved in protein biosynthesis Homo sapiens AMP + diphosphate + L-methionyl-tRNAMet
-
?

Synonyms

Synonyms Comment Organism
Methionine translase
-
Homo sapiens
Methionine--tRNA ligase
-
Homo sapiens
Methionyl tRNA synthetase
-
Homo sapiens
Methionyl-transfer ribonucleate synthetase
-
Homo sapiens
Methionyl-transfer ribonucleic acid synthetase
-
Homo sapiens
Methionyl-transfer RNA synthetase
-
Homo sapiens
MetRS
-
Homo sapiens
Synthetase, methionyl-transfer ribonucleate
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens