Cloned (Comment) | Organism |
---|---|
recombinant overexpression in Escherichia coli | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-bromobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-chlorobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-chloropyridine-3-carboxylate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-fluorobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-methoxybenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-methylbenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-nitrobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-(3-methylphenyl)propanoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-(4-methylphenyl)propanoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-aminobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-bromobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-chlorobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-fluorobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-hydroxybenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-methylbenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-phenylpropanoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-aminobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-bromobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-chlorobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-fluorobenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-hydroxybenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-methylbenzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 6-chloropyridine-3-carboxylate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 6-hydroxypyridine-3-carboxylate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl benzoate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl pyridine-3-carboxylate | - |
Staphylococcus aureus | |
4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl pyridine-4-carboxylate | - |
Staphylococcus aureus | |
additional information | synthesis and evaluation of a series of novel 4-hydroxy-3-(naphthalen-1-ylmethyl)thiophen-2(5H)-ones as tyrosyl-tRNA synthetase inhibitors, molecular docking, structure-activity relationships, overview | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus ATCC 25923 | - |
- |
- |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0111 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-(4-methylphenyl)propanoate | |
0.01898 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-(3-methylphenyl)propanoate | |
0.04332 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl benzoate | |
0.04476 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-hydroxybenzoate | |
0.04894 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-aminobenzoate | |
0.05008 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-methylbenzoate | |
0.05117 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-bromobenzoate | |
0.05523 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-chlorobenzoate | |
0.06514 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 4-fluorobenzoate | |
0.069 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-methylbenzoate | |
0.07109 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-aminobenzoate | |
0.07211 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-hydroxybenzoate | |
0.08214 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-fluorobenzoate | |
0.083 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-phenylpropanoate | |
0.08313 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-bromobenzoate | |
0.08613 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 3-chlorobenzoate | |
0.08862 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-methylbenzoate | |
0.0921 | - |
pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-methoxybenzoate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-bromobenzoate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-chlorobenzoate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-chloropyridine-3-carboxylate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-fluorobenzoate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 2-nitrobenzoate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 6-chloropyridine-3-carboxylate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl 6-hydroxypyridine-3-carboxylate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl pyridine-3-carboxylate | |
0.1 | - |
above, pH 7.9, 37°C, recombinant enzyme | Staphylococcus aureus | 4-[(naphthalen-1-yl)methyl]-5-oxo-2,5-dihydrothiophen-3-yl pyridine-4-carboxylate |