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Literature summary for 6.1.1.1 extracted from

  • Larson, E.T.; Kim, J.E.; Castaneda, L.J.; Napuli, A.J.; Zhang, Z.; Fan, E.; Zucker, F.H.; Verlinde, C.L.; Buckner, F.S.; Van Voorhis, W.C.; Hol, W.G.; Merritt, E.A.
    The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer (2011), J. Mol. Biol., 409, 159-176.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.1

Cloned(Commentary)

Cloned (Comment) Organism
gene structure and motifs in double-length TyrRS homologues, phylogenetic comparison Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
fisetin binding structure, overview Leishmania major
tyrosinol binding structure, overview Leishmania major

Organism

Organism UniProt Comment Textmining
Leishmania major
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information two distinct conformational states of the active site in the three Leishmania major TyrRS structures Leishmania major ?
-
 ?

Subunits

Subunits Comment Organism
More the single tyrosyl-tRNA synthetase gene in trypanosomatid genomes codes for a protein that is twice the length of TyrRS from virtually all other organisms. Each half of the double-length TyrRS contains a catalytic domain and an anticodon-binding domain. Leishmania major TyrRS shows, that the two halves of a single molecule form a pseudo-dimer resembling the canonical TyrRS dimer. The C-terminal copy of the catalytic domain has lost the catalytically important HIGH and KMSKS motifs characteristic of class I aminoacyl-tRNA synthetases. Thus, the TyrRS pseudo-dimer is inherently asymmetric and contains only one functional active site, contributed by the N-terminal half, and only one functional anticodon recognition site, contributed by the C-terminal half Leishmania major

Synonyms

Synonyms Comment Organism
Tyrosyl-tRNA synthetase
-
 Leishmania major
TyrRS
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 Leishmania major

General Information

General Information Comment Organism
evolution phylogenetic relationship of TyrRS sequences, schematic overview Leishmania major