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Literature summary for 6.1.1.1 extracted from
- High glucose inhibits gene expression of tyrosyl-tRNA synthetase in osteoblast cells (2009), Methods Find. Exp. Clin. Pharmacol., 31, 639-644.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | it has been suggested that bone metabolism disorders are one of the major complications of diabetes mellitus, glucose could affect bone metabolism by regulating the expression of tyrosyl-tRNA synthetase genes | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the TOPO TA cloning vector for sequencing | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-tyrosine + tRNATyr | Rattus norvegicus | - |
AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| osteoblast | - |
Rattus norvegicus | - |
| UMR-106 cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-tyrosine + tRNATyr | - |
Rattus norvegicus | AMP + diphosphate + L-tyrosyl-tRNATyr | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tyrosyl-tRNA synthetase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | high glucose significantly decreases mRNA expression of tyrosyl-tRNA synthetase | down |
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Release 2023.1 (January 2023)
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