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Literature summary for 6.1.1.1 extracted from

  • Chadee, A.B.; Bhaskaran, H.; Russell, R.
    Protein roles in group I intron RNA folding: the tyrosyl-tRNA synthetase CYT-18 stabilizes the native state relative to a long-lived misfolded structure without compromising folding kinetics (2010), J. Mol. Biol., 395, 656-670.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.1

Cloned(Commentary)

Cloned (Comment) Organism
CYT-18 is expressed from the plasmid pEX560 in the Escherichia coli strain HMS174DE3 Neurospora crassa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Neurospora crassa 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-tyrosine + tRNATyr Neurospora crassa
-
 AMP + diphosphate + L-tyrosyl-tRNATyr
-
 ?

Organism

Organism UniProt Comment Textmining
Neurospora crassa P12063
-
-

Purification (Commentary)

Purification (Comment) Organism
by ammonium sulfate precipitation and on a heparin-Sepharose column Neurospora crassa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-tyrosine + tRNATyr
-
 Neurospora crassa AMP + diphosphate + L-tyrosyl-tRNATyr
-
 ?

Synonyms

Synonyms Comment Organism
CYT-18
-
 Neurospora crassa
Tyrosyl-tRNA synthetase
-
 Neurospora crassa

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Neurospora crassa

General Information

General Information Comment Organism
physiological function CYT-18 also promotes self-splicing of group I intron RNAs by stabilizing the functional structure in the conserved core Neurospora crassa