Literature summary for 6.1.1.1 extracted from

Paukstelis, P.J.; Chen, J.; Chase, E.; Lambowitz, A.M.; Golden, B.L.
Structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA (2008), Nature, 451, 94-97.

Crystallization (Commentary)

Crystallization (Comment)	Organism
a 4.5 A co-crystal structure of the Twort orf 142-I2 group I intron ribozyme bound to splicing-active, carboxy-terminally truncated CYT-18. Structure shows that the group I intron binds across the two subunits of the homodimeric protein with a newly evolved RNA-binding surface distinct from that which binds tRNATyr. This RNA binding surface provides an extended scaffold for the phosphodiester backbone of the conserved catalytic core of the intron RNA, allowing the protein to promote the splicing of a wide variety of group I introns. The group I intron-binding surface includes three small insertions and additional structural adaptations relative to non-splicing bacterial TyrRSs, indicating a multistep adaptation for splicing function	Neurospora crassa

Crystallization (Comment)

Organism

a 4.5 A co-crystal structure of the Twort orf 142-I2 group I intron ribozyme bound to splicing-active, carboxy-terminally truncated CYT-18. Structure shows that the group I intron binds across the two subunits of the homodimeric protein with a newly evolved RNA-binding surface distinct from that which binds tRNATyr. This RNA binding surface provides an extended scaffold for the phosphodiester backbone of the conserved catalytic core of the intron RNA, allowing the protein to promote the splicing of a wide variety of group I introns. The group I intron-binding surface includes three small insertions and additional structural adaptations relative to non-splicing bacterial TyrRSs, indicating a multistep adaptation for splicing function

Neurospora crassa

Organism

Organism	UniProt	Comment	Textmining
Neurospora crassa	P12063	-	-

Synonyms

Synonyms	Comment	Organism
CYT-18	bifunctional, aminoacylates mitochondrial tRNATyr and promotes the splicing of mitochondrial group I introns	Neurospora crassa
Tyrosyl-tRNA synthetase	-	Neurospora crassa
TyrRS	-	Neurospora crassa

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Release 2023.1 (January 2023)