Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.1 extracted from

  • Cheng, G.; Zhang, H.; Yang, X.; Tzima, E.; Ewalt, K.L.; Schimmel, P.; Faber, J.E.
    Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability (2008), Am. J. Physiol. Regul. Integr. Comp. Physiol., 295, R1138-R1146.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.1

Application

Application Comment Organism
medicine high-dose mini-TyrRS (600 microgram/kg/day) augments while low-dose mini-TyrRS (3 microgram/kg/day), inhibits angiogenesis in the ischemic mouse ear. Enhanced angiogenesis is associated with increased CD45- and CD4-positive leukocyte accumulation. Mini-TyrRS also has biphasic actions on both basal and mustard oil-evoked and VEGF-evoked leakage of Evan's blue dye-albumin in nonischemic ear and in endothelial cell monolayers, that is, low-dose inhibited and high-dose augmented leakage. Mini-TyrRS has dose-dependent biphasic effects on ischemic angiogenesis and vascular permeability in vivo, that is, antiangiogenic and antipermeability activities at low concentration and proangiogenic, propermeability activities at high concentrations Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information mutation of the ELR-motif to EYR abolishes the effect on ischemic angiogenesis, leukocyte recruitment, and vascular permeability Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Mus musculus
-
muscle mini-TyrRS is reduced in extracts of ischemic calf muscle and in thoracic aorta explants exposed to hypoxia or VEGF Mus musculus
-

Synonyms

Synonyms Comment Organism
mini-tyrosyl-tRNA synthetase N-terminal domain of tyrosyl-tRNA synthetase Mus musculus
mini-TyrRS
-
 Mus musculus