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Literature summary for 6.1.1.1 extracted from

  • Qiu, X.; Janson, C.A.; Smith, W.W.; Green, S.M.; McDevitt, P.; Johanson, K.; Carter, P.; Hibbs, M.; Lewis, C.; Chalker, A.; Fosberry, A.; Lalonde, J.; Berge, J.; Brown, P.; Houge-Frydrych, C.S.; Jarvest, R.L.
    Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors (2001), Protein Sci., 10, 2008-2016.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.1

Application

Application Comment Organism
pharmacology design of antimicrobial agents against Staphylococcus aureus, largely responsible for hospital-acquired infections, on the basis of knowledge of the crystal structure and the revealed catalytic mechanism Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure determination by X-ray diffraction, enzyme complexed with inhibitors at 2.8 A resolution, and truncated enzyme complexed with inhibitors at 2.2 A resolution Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme-inhibitor complexes Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tyrosine + tRNATyr Staphylococcus aureus
-
 AMP + Tyr-tRNATyr + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + L-tyrosine + tRNATyr = AMP + diphosphate + L-tyrosyl-tRNATyr mechanism Staphylococcus aureus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tyrosine + tRNATyr
-
 Staphylococcus aureus AMP + Tyr-tRNATyr + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
Tyrosine tRNA synthetase
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Staphylococcus aureus