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Literature summary for 6.1.1.1 extracted from

  • Ewalt, K.L.; Schimmel, P.
    Activation of angiogenic signaling pathways by two human tRNA synthetases (2002), Biochemistry, 41, 13344-13349.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the C-terminal EMAP II-like protein domain of the enzyme is probably responsible for mediation of enzyme export Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tyrosine + tRNATyr Homo sapiens
-
AMP + Tyr-tRNATyr + diphosphate
-
?
additional information Homo sapiens the enzyme's C-terminal domain, an EMAP II-like protein, is active in angiogenesis pathways and stimulates immune cells, when cleaved off the enzyme, it stimulates blood vessel development ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
the enzyme's C-terminal domain is a endothelial monocyte activating polypeptide II-like, i.e. an EMAP II-like, protein with cytokine activity
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the C-terminal domain of the enzyme, which has cytokine and angiogenic activity and stimulates immune cells, is isolated by proteolytic cleavage or alternative splicing, the mini enzyme is a stimulator of blood vessel development, the full-length enzyme is inactive Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tyrosine + tRNATyr
-
Homo sapiens AMP + Tyr-tRNATyr + diphosphate
-
?
additional information the enzyme's C-terminal domain, an EMAP II-like protein, is active in angiogenesis pathways and stimulates immune cells, when cleaved off the enzyme, it stimulates blood vessel development Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Tyrosyl-tRNA synthetase
-
Homo sapiens
TyrRS
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens