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Literature summary for 5.6.2.2 extracted from

  • Bandele, O.J.; Clawson, S.J.; Osheroff, N.
    Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement (2008), Chem. Res. Toxicol., 21, 1253-1260.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin redox-dependent topoisomerase II poison Homo sapiens
(-)-epigallocatechin gallate redox-dependent topoisomerase II poison Homo sapiens
kaempferol
-
Homo sapiens
additional information not inhibited by (-)-epicatechin gallate and (-)-epicatechin Homo sapiens
myricetin
-
Homo sapiens
quercetin
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA + ATP + H2O
-
Homo sapiens catenated DNA networks + ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
topoisomerase IIalpha
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens