Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | myosin II seems to be activated by a rapid actin-linked mechanism rather than slow myosin light chain phosphorylation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-(2)-blebbistatin | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + myosin bound to actin filament at position n | Rattus norvegicus | - |
ADP + phosphate + myosin bound to actin filament at position n+1 | - |
? | |
ATP + H2O + myosin bound to actin filament at position n | Rattus norvegicus Wistar | - |
ADP + phosphate + myosin bound to actin filament at position n+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Wistar | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampal cell line | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
spinal column | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + myosin bound to actin filament at position n | - |
Rattus norvegicus | ADP + phosphate + myosin bound to actin filament at position n+1 | - |
? | |
ATP + H2O + myosin bound to actin filament at position n | - |
Rattus norvegicus Wistar | ADP + phosphate + myosin bound to actin filament at position n+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
myosin II ATPase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | in drebrin A (DA-actin) from dendritic spines, DA-actin exodus is blocked by myosin II ATPase inhibitor, but is not blocked by myosin light chain kinase or Rho-associated kinase inhibitors, indicating that myosin II mediates the interaction between NMDA receptor activation and DA-actin exodus in long-term potentiation induction. Glutamate-induced DA-actin exodus is also dependent on myosin II ATPase activity. Myosin II seems to be activated by a rapid actin-linked mechanism rather than slow myosin light chain phosphorylation. The myosin-II mediated DA-actin exodus might be an initial event in LTP induction, triggering actin polymerization and spine enlargement | Rattus norvegicus |