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Literature summary for 5.6.1.8 extracted from

  • Kiani, F.A.; Fischer, S.
    Advances in quantum simulations of ATPase catalysis in the myosin motor (2015), Curr. Opin. Struct. Biol., 31, 115-123.
    View publication on PubMed
Search for more literature for 5.6.1.8

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis, in which myosin II from Dictyostelium discoideum is complexed with Mg2-ADP-vanadate, a transition state analogue, PDB ID 1VOM Dictyostelium discoideum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required, Mg2+ coordination sphere, binding structure, overview Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + myosin bound to actin filament at position n Dictyostelium discoideum
-
 ADP + phosphate + myosin bound to actin filament at position n+1
-
 ?
additional information Dictyostelium discoideum during its contraction cycle, the myosin motor catalyzes the hydrolysis of ATP ?
-
 ?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum P08799
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + myosin bound to actin filament at position n = ADP + phosphate + myosin bound to actin filament at position n+1 combined quantum/classical mechanics study and catalytic mechanism, detailed overview and analysis Dictyostelium discoideum
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + myosin bound to actin filament at position n
-
 Dictyostelium discoideum ADP + phosphate + myosin bound to actin filament at position n+1
-
 ?
ATP + H2O + myosin bound to actin filament at position n ATP binding site of myosin and catalytically active conformation, modeling and analysis of crystal structure, PDB 1VOM Dictyostelium discoideum ADP + phosphate + myosin bound to actin filament at position n+1
-
 ?
additional information during its contraction cycle, the myosin motor catalyzes the hydrolysis of ATP Dictyostelium discoideum ?
-
 ?

General Information

General Information Comment Organism
additional information combined quantum/classical mechanics study and catalytic mechanism overview Dictyostelium discoideum
physiological function myosin is a linear motor that utilizes the free energy obtained from ATP hydrolysis to drive the coordinated motion of its protein domains during muscle contraction. During its contraction cycle, the myosin motor catalyzes the hydrolysis of ATP, molecular mechanism involving residue Glu459, overview Dictyostelium discoideum