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Literature summary for 5.6.1.8 extracted from

  • Anderson, T.W.; Vaughan, A.N.; Cramer, L.P.
    Retrograde flow and myosin II activity within the leading cell edge deliver F-actin to the lamella to seed the formation of graded polarity actomyosin II filament bundles in migrating fibroblasts (2008), Mol. Biol. Cell, 19, 5006-5018.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
blebbistatin 100 micromol reduces appearance of new graded polarity (actomyosin) bundles within the lamella 10-fold Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane cell edge Gallus gallus
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + myosin bound to actin filament at position n Gallus gallus Delivering of F-actin to the lamella of migrating fibroblasts ADP + phosphate + myosin bound to actin filament at position n+1
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?

Organism

Organism UniProt Comment Textmining
Gallus gallus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast prepared from embryonal chicken hearts Gallus gallus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + myosin bound to actin filament at position n Delivering of F-actin to the lamella of migrating fibroblasts Gallus gallus ADP + phosphate + myosin bound to actin filament at position n+1
-
?

Synonyms

Synonyms Comment Organism
myosin II ATPase
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Gallus gallus