Application | Comment | Organism |
---|---|---|
medicine | the enzyme serves as a prognostic indicator for radiotherapy and molecular targeted therapy in lung cancer patients | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | Homo sapiens | - |
ADP + phosphate + unfolded polypeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
H-460 cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | - |
Homo sapiens | ADP + phosphate + unfolded polypeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
19S proteasome ATPase | - |
Homo sapiens |
proteasome 26S subunit, ATPase 5 | - |
Homo sapiens |
PSMC5 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | subunit PSMC5 depletion in H-460 cells enhances both AKT activation and MDM2 transcription, thereby promoting the degradation of p53 and p21 proteins | Homo sapiens |
physiological function | subunit PSMC5 facilitates the damaging effects of radiation in radiation-responsive H-460 cancer cells | Homo sapiens |