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Literature summary for 5.6.1.5 extracted from
- Radiosensitizing effect of PSMC5, a 19S proteasome ATPase, in H460 lung cancer cells (2016), Biochem. Biophys. Res. Commun., 469, 94-100 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme serves as a prognostic indicator for radiotherapy and molecular targeted therapy in lung cancer patients | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | Homo sapiens | - |
ADP + phosphate + unfolded polypeptide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| H-460 cell | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | - |
Homo sapiens | ADP + phosphate + unfolded polypeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 19S proteasome ATPase | - |
Homo sapiens |
| proteasome 26S subunit, ATPase 5 | - |
Homo sapiens |
| PSMC5 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | subunit PSMC5 depletion in H-460 cells enhances both AKT activation and MDM2 transcription, thereby promoting the degradation of p53 and p21 proteins | Homo sapiens |
| physiological function | subunit PSMC5 facilitates the damaging effects of radiation in radiation-responsive H-460 cancer cells | Homo sapiens |
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