Crystallization (Comment) | Organism |
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crystal structure of the archaeal 20S proteasome in complex with the C-terminus of the archaeal proteasome regulatory ATPase, PAN is determined. This structure defines the detailed interactions between the critical C-terminal HbYX motif and the 20S a-subunits and indicates that the intersubunit pocket in the 20S undergoes an induced-fit conformational change on binding of the HbYX motif | Methanocaldococcus jannaschii |
Protein Variants | Comment | Organism |
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additional information | six mutants of the PAN ATPases, in which PAN's seven C-terminal residues are replaced by the corresponding C-terminal residues of one of the yeast ATPases, Rpt1-Rpt6: Wild-type PAN and the PANRpt5 stimulate gate opening of the alpha3-alpha4 20S pocket mutant. None of the PANRpt mutants or wild-type PAN stimulate gate opening of 20S alpha1-alpha2 pocket mutant, and PANRpt2 stimulates gate opening of wild-type 20S, but not the alpha3-alpha4 pocket mutant. Only PANRpt5 is found to bind to one or both ends of the 20S alpha3-alpha4 pocket mutant, whereas none of the PANRpts forms a complex with the alpha1-alpha2 pocket mutant | Methanocaldococcus jannaschii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
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Organism | UniProt | Comment | Textmining |
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Methanocaldococcus jannaschii | - |
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Synonyms | Comment | Organism |
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PAN | - |
Methanocaldococcus jannaschii |