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Literature summary for 5.6.1.5 extracted from

  • Vernace, V.A.; Arnaud, L.; Schmidt-Glenewinkel, T.; Figueiredo-Pereira, M.E.
    Aging perturbs 26S proteasome assembly in Drosophila melanogaster (2007), FASEB J., 21, 2672-2682.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.5

Application

Application Comment Organism
medicine the finding that the disassembly of the 26S proteasome is an old-age event could explain the presence of protein deposits containing ubiquitinated proteins and oxidatively modified proteins in nonpathologic aging, as well as in a variety of aging-related neurodegenerative disorders Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
additional information a decline in proteasome activity with the aging process is shown Drosophila melanogaster
PSI proteasome inhibitor Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + polypeptide Drosophila melanogaster
-
 ADP + phosphate + unfolded polypeptide
-
 ir

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + polypeptide
-
 Drosophila melanogaster ADP + phosphate + unfolded polypeptide
-
 ir

Synonyms

Synonyms Comment Organism
26S proteasome
-
 Drosophila melanogaster
proteasome ATPase
-
 Drosophila melanogaster

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 in-gel proteasome activity assay Drosophila melanogaster

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 in-gel proteasome activity assay Drosophila melanogaster