Literature summary for 5.6.1.5 extracted from

Nakamura, Y.; Umehara, T.; Tanaka, A.; Horikoshi, M.; Padmanabhan, B.; Yokoyama, S.
Structural basis for the recognition between the regulatory particles Nas6 and Rpt3 of the yeast 26S proteasome (2007), Biochem. Biophys. Res. Commun., 359, 503-509.

Search for more literature for 5.6.1.5

Application

Application	Comment	Organism
medicine	the human orthologue of yeast Rpt3, S6 ATPase, interacts with the oncoprotein gankyrin, gankyrin is commonly overexpressed in hepatocellular cancer cells	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
-	Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
E365A/D367A	mutant constructed for interaction studies between the C-terminal domain of Rpt3 and Nas6, the complex is completely disrupted for this mutant	Saccharomyces cerevisiae
K397A/R399A	mutant constructed for interaction studies between the C-terminal domain of Rpt3 and Nas6, the complex is completely disrupted for this mutant	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + polypeptide	Saccharomyces cerevisiae	-	ADP + phosphate + unfolded polypeptide	-	ir

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + polypeptide	-	Saccharomyces cerevisiae	ADP + phosphate + unfolded polypeptide	-	ir

Synonyms

Synonyms	Comment	Organism
26S proteasome	-	Saccharomyces cerevisiae
ATPase subunit Rpt3	-	Saccharomyces cerevisiae
proteasome ATPase	-	Saccharomyces cerevisiae
Rpt3	-	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)