Literature summary for 5.6.1.5 extracted from

Mueller, D.; Nagel, A.C.; Maier, D.; Preiss, A.
A molecular link A molecular link between Hairless and Pros26.4, a member of the AAA-ATPase subunits of the proteasome 19S regulatory particle in Drosophila (2006), J. Cell Sci., 119, 250-258.

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Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + polypeptide	Pros26.4 negatively regulates Hairless at the genetic and molecular level. Depletion of Pros26.4 results in a specific stabilization of the Hairless protein, but not in stabilization of the intracellular domain of Notch or the effector protein Suppressor of Hairless. Thus, the Hairless-Pros26.4 interaction provides a novel mechanism of positive regulation of Notch signalling	Drosophila melanogaster	ADP + phosphate + unfolded polypeptide	-	?

Synonyms

Synonyms	Comment	Organism
Pros26.4	one of six AAA-ATPases that form the base of the 19S regulatory particle of the 26S proteasome	Drosophila melanogaster

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Release 2023.1 (January 2023)