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Literature summary for 5.6.1.5 extracted from

  • Kohler, A.; Cascio, P.; Leggett, D.S.; Woo, K.M.; Goldberg, A.L.; Finley, D.
    The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release (2001), Mol. Cell, 7, 1143-1152.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K229R lysine residue is essentiel for ATP hydrolysis, mutation is lethal Saccharomyces cerevisiae
S241F mutation suppresses K229R lethality, mutant has no known phenotype in the absence of K229R mutation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + polypeptide Saccharomyces cerevisiae
-
ADP + phosphate + unfolded polypeptide
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + polypeptide
-
Saccharomyces cerevisiae ADP + phosphate + unfolded polypeptide
-
?
ATP + H2O + polypeptide Rpt2 controls the gating of the adjacent core particle channnel of the proteasome Saccharomyces cerevisiae ADP + phosphate + unfolded polypeptide
-
?

Synonyms

Synonyms Comment Organism
Rpt2
-
Saccharomyces cerevisiae