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Literature summary for 5.6.1.5 extracted from

  • Benaroudj, N.; Zwickl, P.; Seemuller, E.; Baumeister, W.; Goldberg, A.L.
    ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation (2003), Mol. Cell, 11, 69-78.
    View publication on PubMed
Search for more literature for 5.6.1.5

Activating Compound

Activating Compound Comment Organism Structure
casein 1000fold molar excess, 5fold stimulation of ATPase activity Methanocaldococcus jannaschii
GFPssrA green fluoresence protein with C-terminus fused to the 11 residue peptide ssrA, 5fold stimulation of ATPase activity Methanocaldococcus jannaschii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 650000 Da ATPase comlex Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + polypeptide Methanocaldococcus jannaschii
-
 ADP + phosphate + unfolded polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Methanocaldococcus jannaschii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Methanocaldococcus jannaschii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + polypeptide
-
 Methanocaldococcus jannaschii ADP + phosphate + unfolded polypeptide
-
 ?
ATP + H2O + polypeptide ATP hydrolysis promotes 3 processes in the 20S proteasome, substrate unfolding, gate opening and protein translocation Methanocaldococcus jannaschii ADP + phosphate + unfolded polypeptide
-
 ?

Synonyms

Synonyms Comment Organism
PAN
-
 Methanocaldococcus jannaschii
proteasome activating nucleotidase
-
 Methanocaldococcus jannaschii