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Literature summary for 5.6.1.5 extracted from
- Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases (2001), Chem. Biol., 8, 941-950.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| T193C | 25% increase in N-ethylmaleimide sensitivity | Saccharomyces cerevisiae |
| T226C | 25% increase in N-ethylmaleimide sensitivity | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | alkylation of Sug1 or Sug2 leads to inhibition of 26S peptidase activity by different mechanisms | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | Saccharomyces cerevisiae | - |
ADP + phosphate + unfolded polypeptide | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | - |
Saccharomyces cerevisiae | ADP + phosphate + unfolded polypeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Sug1/Rpt6 | - |
Saccharomyces cerevisiae |
| Sug2/Rpt4 | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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