Application | Comment | Organism |
---|---|---|
medicine | molecular analysis of this parasite, new means to combat drug resistance in malaria, PSF4 may be a target for the development of new antimalarial drugs that will be effective against chloroquine-resistant parasites | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
cloning of a cDNA encoding the proteasome subunit 4 ATPase, gene PSF4, PCR and DNA sequencing | Plasmodium falciparum |
Crystallization (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lactacystin | - |
Entamoeba histolytica | |
lactacystin | specific inhibitor of the eukaryotic proteasome | Plasmodium falciparum | |
lactacystin | - |
Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Plasmodium falciparum | 5829 | - |
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
nucleus | - |
Plasmodium falciparum | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
S4 ATPase, SDS-PAGE | Plasmodium falciparum |
700000 | - |
regulatory complex PA700 | Saccharomyces cerevisiae |
2000000 | - |
26S proteasome, ATP-dependent proteolytic complex | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | Drosophila sp. (in: flies) | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Mus musculus | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Homo sapiens | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Saccharomyces cerevisiae | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Entamoeba histolytica | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Trypanosoma cruzi | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Plasmodium falciparum | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | Oryza sativa | - |
ADP + phosphate + unfolded polypeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila sp. (in: flies) | - |
- |
- |
Entamoeba histolytica | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
mouse | - |
Oryza sativa | - |
rice | - |
Plasmodium falciparum | - |
most lethal form of human malaria | - |
Saccharomyces cerevisiae | - |
- |
- |
Trypanosoma cruzi | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Drosophila sp. (in: flies) | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Mus musculus | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Homo sapiens | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Saccharomyces cerevisiae | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Entamoeba histolytica | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Trypanosoma cruzi | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Plasmodium falciparum | |
ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Oryza sativa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + polypeptide | - |
Drosophila sp. (in: flies) | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Mus musculus | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Homo sapiens | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Saccharomyces cerevisiae | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Entamoeba histolytica | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Trypanosoma cruzi | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Plasmodium falciparum | ADP + phosphate + unfolded polypeptide | - |
? | |
ATP + H2O + polypeptide | - |
Oryza sativa | ADP + phosphate + unfolded polypeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
26S proteasome | - |
Homo sapiens |
26S proteasome | - |
Saccharomyces cerevisiae |
26S proteasome | - |
Plasmodium falciparum |
proteasome S4 ATPase | - |
Drosophila sp. (in: flies) |
proteasome S4 ATPase | - |
Mus musculus |
proteasome S4 ATPase | - |
Homo sapiens |
proteasome S4 ATPase | - |
Saccharomyces cerevisiae |
proteasome S4 ATPase | - |
Plasmodium falciparum |
proteasome S4 ATPase | - |
Oryza sativa |