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Literature summary for 5.6.1.5 extracted from
- cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p (1995), FEBS Lett., 363, 151-156.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| 5 genes cloned encoding 26S proteasome components | Saccharomyces cerevisiae |
| cDNA encoding regulatory subunit p45 | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45160 | - |
TBP-1, calculated from amino acid sequence | Homo sapiens |
| 45230 | - |
SUG1, calculated from amino acid sequence | Saccharomyces cerevisiae |
| 45770 | - |
p45, predicted from the open reading frame | Homo sapiens |
| 47970 | - |
YTA2, calculated from amino acid sequence | Saccharomyces cerevisiae |
| 48260 | - |
YTA1, calculated from amino acid sequence | Saccharomyces cerevisiae |
| 48630 | - |
MSS1, calculated from amino acid sequence | Homo sapiens |
| 48830 | - |
YTA5, calculated from amino acid sequence | Saccharomyces cerevisiae |
| 49240 | - |
S4, calculated from amino acid sequence | Homo sapiens |
| 51550 | - |
TBP-7, calculated from amino acid sequence | Homo sapiens |
| 51730 | - |
CIM5, calculated from amino acid sequence | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | Homo sapiens | - |
ADP + phosphate + unfolded polypeptide | - |
? |  |
| ATP + H2O + polypeptide | Saccharomyces cerevisiae | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Bos taurus | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Schizosaccharomyces pombe | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | Manduca sexta | - |
ADP + phosphate + unfolded polypeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
| Homo sapiens | - |
human, hepatoblastoma HepG2 cells | - |
| Manduca sexta | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Schizosaccharomyces pombe | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Homo sapiens | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Saccharomyces cerevisiae | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Bos taurus | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Schizosaccharomyces pombe | |
| ATP + H2O + polypeptide = ADP + phosphate + unfolded polypeptide | belongs to the AAA-type superfamily and, like EC 3.6.4.5, minus-end-directed kinesin ATPase, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome | Manduca sexta |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + polypeptide | - |
Homo sapiens | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Saccharomyces cerevisiae | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Bos taurus | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Schizosaccharomyces pombe | ADP + phosphate + unfolded polypeptide | - |
? | |
| ATP + H2O + polypeptide | - |
Manduca sexta | ADP + phosphate + unfolded polypeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor Sug1p | - |
Saccharomyces cerevisiae |
| p45 | - |
Homo sapiens |
| p45 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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