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Literature summary for 5.6.1.4 extracted from

  • Thrower, D.A.; Jordan, M.A.; Schaar, B.T.; Yen, T.J.; Wilson, L.
    Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor (1995), EMBO J., 14, 918-926.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.4

Inhibitors

Inhibitors Comment Organism Structure
5'-adenylylimidodiphosphate
-
 Homo sapiens
N-ethylmaleimide
-
 Homo sapiens
VO43-
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytoplasm
-
 Dictyostelium sp. 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31200
-
 calculated from predicted amino acid sequence Homo sapiens
87400
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Homo sapiens
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n Xenopus laevis
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n Dictyostelium sp.
-
 ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Dictyostelium sp.
-
-
-
Homo sapiens
-
 human, HeLa cells
-
Xenopus laevis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Homo sapiens
a
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Xenopus laevis
a
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules Dictyostelium sp.
a

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
 Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-dideoxy-ATP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens 2',3'-dideoxy-ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Homo sapiens ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Xenopus laevis ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Dictyostelium sp. ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end)
-
 ?
additional information GTP, 8-bromo ATP, 1,N6-etheno-adenosine 5'-triphosphate and 5'-O-(3-thiotriphosphate) are no substrates Homo sapiens ?
-
 ?