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Literature summary for 5.6.1.3 extracted from

  • Vale, R.D.; Reese, T.S.; Sheetz, M.P.
    Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility (1985), Cell, 42, 39-50.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.3

Inhibitors

Inhibitors Comment Organism Structure
adenylylimidodiphosphate AMP-PNP Doryteuthis pealeii
N-ethylmaleimide
-
 Doryteuthis pealeii
V5+
-
 Bos taurus
V5+
-
 Doryteuthis pealeii

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Doryteuthis pealeii 5737
-
cytoplasm axoplasm Doryteuthis pealeii 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 6 * 110000, SDS-PAGE Doryteuthis pealeii
120000
-
-
 Doryteuthis pealeii
120000
-
 gel filtration Bos taurus
600000
-
 gel filtration Doryteuthis pealeii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n Bos taurus
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n Doryteuthis pealeii
-
 ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n Bos taurus
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n Doryteuthis pealeii
-
 GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine
-
Doryteuthis pealeii
-
 squid
-

Purification (Commentary)

Purification (Comment) Organism
-
 Doryteuthis pealeii

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Bos taurus
a
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end) microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (a) chains (110kDa) and two more light (b) chains (65-75 kDa). Also hydrolyzes GTP. Doryteuthis pealeii
a

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-
optic lobe
-
 Doryteuthis pealeii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Bos taurus ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
ATP + H2O + a kinesin associated with a microtubule at position n
-
 Doryteuthis pealeii ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n
-
 Bos taurus GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?
GTP + H2O + a kinesin associated with a microtubule at position n
-
 Doryteuthis pealeii GDP + phosphate a kinesin associated with a microtubule at position n+1 (toward the plus end)
-
 ?

Subunits

Subunits Comment Organism
hexamer 6 * 110000, SDS-PAGE Doryteuthis pealeii