Literature summary for 5.6.1.1 extracted from

Mannan, A.U.; Boehm, J.; Sauter, S.M.; Rauber, A.; Byrne, P.C.; Neesen, J.; Engel, W.
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein (2006), Neurogenetics, 7, 93-103.

Search for more literature for 5.6.1.1

Application

Application	Comment	Organism
medicine	spastin is the most commonly mutated protein in hereditary spastic paraplegia	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
spastin cDNA is cloned into the pGEMT easy vector, for generating a bait construct for yeast two-hybrid analysis, the excised spastin fragment is cloned into the pGBKT7 vector, for expression analysis in mammalian cells, the fragment is cloned into the pCS2-myc and pEGFP-C1 vectors	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
spastin-DELTAAAA	spastin variant without AAA ATPase domain	Homo sapiens
spastin-DELTACT	C-terminal spastin deletion mutant, aa 398-583 deleted	Homo sapiens
spastin-DELTAexon4	spastin variant without exon4	Homo sapiens
spastin-DELTANT	N-terminal spastin deletion mutant, aa 1-300 deleted	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
cytoplasmic vesicle	-	Homo sapiens	31410	-
nucleus	-	Homo sapiens	5634	-
synapse	synaptic terminal of neutrons	Homo sapiens	45202	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O	Homo sapiens	-	ADP + phosphate	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	-	Homo sapiens	ADP + phosphate	-	ir

Synonyms

Synonyms	Comment	Organism
spastin	-	Homo sapiens

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Release 2023.1 (January 2023)