Application | Comment | Organism |
---|---|---|
medicine | mutations in the SPG4 gene, spastin is the SPG4 gene product, are the most common cause of autosomal dominant hereditary spastic paraplegia, HSP | Danio rerio |
Cloned (Comment) | Organism |
---|---|
TA-cloned for sequencing, subcloned into pFLAG-CMV-6a for transfection of HEK293 cells | Danio rerio |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
spg4atg1 | morpholino antisense oligonucleotide for blocking translation of spg4 mRNA | Danio rerio | |
spg4exon7 | morpholino antisense oligonucleotide for blocking correct splicing of spg4 mRNA | Danio rerio |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Danio rerio | - |
ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | Q6NW58 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Danio rerio | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Danio rerio | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
microtubule severing protein | shares homology with katanin | Danio rerio |
spastin | - |
Danio rerio |