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Literature summary for 5.6.1.1 extracted from
- Cellular Samurai: katanin and the severing of microtubules (2000), J. Cell Sci., 113, 2821-2827.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Mei-1 and Mei-2 cloned and coexpressed in HeLa cells | Caenorhabditis elegans |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
1 * 80000 + 1 * 60000, SDS-PAGE | Chlamydomonas reinhardtii |
| 80000 | - |
1 * 80000 + 1 * 60000, SDS-PAGE | Chlamydomonas reinhardtii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Chlamydomonas reinhardtii | - |
ADP + phosphate | - |
? |  |
| ATP + H2O | Drosophila sp. (in: flies) | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Homo sapiens | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Xenopus laevis | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Caenorhabditis elegans | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Arabidopsis sp. | - |
ADP + phosphate | - |
? | |
| GTP + H2O | Chlamydomonas reinhardtii | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Drosophila sp. (in: flies) | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Homo sapiens | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Xenopus laevis | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Caenorhabditis elegans | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Arabidopsis sp. | - |
GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis sp. | - |
- |
- |
| Caenorhabditis elegans | - |
- |
- |
| Chlamydomonas reinhardtii | - |
- |
- |
| Drosophila sp. (in: flies) | - |
- |
- |
| Homo sapiens | - |
human | - |
| no activity in Saccharomyces cerevisiae | - |
- |
- |
| Xenopus laevis | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Chlamydomonas reinhardtii | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Drosophila sp. (in: flies) | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Homo sapiens | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Xenopus laevis | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Caenorhabditis elegans | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Arabidopsis sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | - |
Xenopus laevis | - |
| epithelium | - |
Homo sapiens | - |
| fibroblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Chlamydomonas reinhardtii | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Drosophila sp. (in: flies) | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Homo sapiens | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Xenopus laevis | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Caenorhabditis elegans | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Arabidopsis sp. | ADP + phosphate | - |
? | |
| GTP + H2O | - |
Chlamydomonas reinhardtii | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Drosophila sp. (in: flies) | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Xenopus laevis | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Caenorhabditis elegans | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Arabidopsis sp. | GDP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Xenopus laevis |
| dimer | 1 * 80000 + 1 * 60000, SDS-PAGE | Chlamydomonas reinhardtii |
| dimer | Mei-1 + Mei-2, heterodimer analogous to p60/p80 | Caenorhabditis elegans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mei-1 | - |
Caenorhabditis elegans |
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