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Literature summary for 5.6.1.1 extracted from

  • McNally, F.J.; Thomas, S.
    Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs (1998), Mol. Biol., 9, 1847-1861.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.1

Cloned(Commentary)

Cloned (Comment) Organism
human cDNA PCR amplified Homo sapiens
isolation of cDNA clones for the p60 and p80 subunits, heterologous expression of p60 in Sf9 cell baculovirus system Strongylocentrotus purpuratus

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
 Xenopus laevis 5813
-
centrosome
-
 Strongylocentrotus purpuratus 5813
-
centrosome
-
 Homo sapiens 5813
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 1 * 80000 + 1 * 60000, SDS-PAGE Chlamydomonas reinhardtii
60000
-
 1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus
80000
-
 1 * 80000 + 1 * 60000, SDS-PAGE Chlamydomonas reinhardtii
80000
-
 1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Gallus gallus
-
 ADP + phosphate
-
 ?
ATP + H2O Chlamydomonas reinhardtii
-
 ADP + phosphate
-
 ?
ATP + H2O Mus musculus
-
 ADP + phosphate
-
 ?
ATP + H2O Xenopus laevis
-
 ADP + phosphate
-
 ?
ATP + H2O Caenorhabditis elegans
-
 ADP + phosphate
-
 ?
ATP + H2O Strongylocentrotus purpuratus
-
 ADP + phosphate
-
 ?
ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?
GTP + H2O Gallus gallus
-
 GDP + phosphate
-
 ?
GTP + H2O Chlamydomonas reinhardtii
-
 GDP + phosphate
-
 ?
GTP + H2O Mus musculus
-
 GDP + phosphate
-
 ?
GTP + H2O Xenopus laevis
-
 GDP + phosphate
-
 ?
GTP + H2O Caenorhabditis elegans
-
 GDP + phosphate
-
 ?
GTP + H2O Strongylocentrotus purpuratus
-
 GDP + phosphate
-
 ?
GTP + H2O Homo sapiens
-
 GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Chlamydomonas reinhardtii
-
-
-
Gallus gallus
-
 chicken
-
Homo sapiens O75449 human
-
Homo sapiens O75449 human cell lines MSU1.1 and HeLa
-
Mus musculus
-
 mouse, neuroblastoma
-
Strongylocentrotus purpuratus
-
 sea urchin
-
Xenopus laevis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Xenopus laevis

Reaction

Reaction Comment Organism Reaction ID
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Gallus gallus
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Chlamydomonas reinhardtii
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Mus musculus
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Xenopus laevis
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Caenorhabditis elegans
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Strongylocentrotus purpuratus
a
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-
egg
-
 Xenopus laevis
-
egg
-
 Strongylocentrotus purpuratus
-
embryo
-
 Strongylocentrotus purpuratus
-
epithelium
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Gallus gallus ADP + phosphate
-
 ?
ATP + H2O
-
 Chlamydomonas reinhardtii ADP + phosphate
-
 ?
ATP + H2O
-
 Mus musculus ADP + phosphate
-
 ?
ATP + H2O
-
 Xenopus laevis ADP + phosphate
-
 ?
ATP + H2O
-
 Caenorhabditis elegans ADP + phosphate
-
 ?
ATP + H2O
-
 Strongylocentrotus purpuratus ADP + phosphate
-
 ?
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?
GTP + H2O
-
 Gallus gallus GDP + phosphate
-
 ?
GTP + H2O
-
 Chlamydomonas reinhardtii GDP + phosphate
-
 ?
GTP + H2O
-
 Mus musculus GDP + phosphate
-
 ?
GTP + H2O
-
 Xenopus laevis GDP + phosphate
-
 ?
GTP + H2O
-
 Caenorhabditis elegans GDP + phosphate
-
 ?
GTP + H2O
-
 Strongylocentrotus purpuratus GDP + phosphate
-
 ?
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Xenopus laevis
dimer
-
 Caenorhabditis elegans
dimer 1 * 80000 + 1 * 60000, SDS-PAGE Chlamydomonas reinhardtii
dimer 1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus

Synonyms

Synonyms Comment Organism
mei-1
-
 Caenorhabditis elegans
vertebrate katanin
-
 Homo sapiens