Literature summary for 5.5.1.8 extracted from

Weitman, M.; Major, D.T.
Challenges posed to bornyl diphosphate synthase: diverging reaction mechanisms in monoterpenes (2010), J. Am. Chem. Soc., 132, 6349-6360.

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Organism

Organism	UniProt	Comment	Textmining
Salvia officinalis	O81192	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranyl diphosphate	-	Salvia officinalis	(+)-bornyl diphosphate	-	?
additional information	the reaction mechanism in BPPS involves the following steps: binding of geranyl diphospahte, metal-activated ionization to yield an allylic transoid carbocation, formation of (3R)-linalyl diphosphate, rotation around the C2-C3 bond and ionization to generate a cisoid allylic cation in the reactive conformation, cyclization to form a (4R)-R-terpinyl cation, further cyclization to yield (+)-2-bornyl cation, and reincorporation of the diphosphate by the (+)-2-bornyl carbocation, to yield the final product (+)-bornyl diphosphate in ca. 75% yield	Salvia officinalis	?	-	?

Synonyms

Synonyms	Comment	Organism
(+)-bornyl diphosphate synthase	-	Salvia officinalis
BPPS	-	Salvia officinalis

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Release 2023.1 (January 2023)