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Literature summary for 5.5.1.4 extracted from

  • Luo, Y.; Qin, G.; Zhang, J.; Liang, Y.; Song, Y.; Zhao, M.; Tsuge, T.; Aoyama, T.; Liu, J.; Gu, H.; Qu, L.J.
    D-myo-Inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis (2011), Plant Cell, 23, 1352-1372.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
MIPS genes mips1, mips2, and mips3, phylogenetic analysis, the three Arabidopsis thaliana MIPS genes show dynamic expression patterns during Arabidopsis embryo development. They all functionally rescue the yeast ino1 mutant, which is defective in yeast MIPS gene INO1 Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information single mips mutants show no obvious phenotypes, but mips1 mips2 double mutant and the mips1 mips2 mips3 triple mutant are embryo lethal, whereas the mips1 mips3 and mips1 mips2+/- double mutants has abnormal embryos. The double and triple mips mutants display abnormal expression patterns of DR5:GFP, an auxin-responsive fusion protein, and they have altered PIN1 subcellular localization. Also, membrane trafficking is affected in mips1 mips3, overview. overexpression of phosphatidylinositol synthase 2, which converts myoinositol to membrane phosphatidylinositol, largely rescued the cotyledon and endomembrane defects in mips1 mips3 Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Arabidopsis thaliana 16020
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana F4IIN3 gene mips2; three MIPS genes mips1, mips2, and mips3
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Arabidopsis thaliana P42801 gene mips1; three MIPS genes mips1, mips2, and mips3
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Arabidopsis thaliana Q9LX12 gene mips3; three MIPS genes mips1, mips2, and mips3
-

Source Tissue

Source Tissue Comment Organism Textmining
cotyledon
-
 Arabidopsis thaliana
-
rosette leaf
-
 Arabidopsis thaliana
-

Synonyms

Synonyms Comment Organism
D-myo-inositol-3-phosphate synthase
-
 Arabidopsis thaliana
MIPS
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction endomembrane function in embryo cells is impaired in the mips1mips3 double mutant. Mips1 mips2 double mutant and the mips1 mips2 mips3 triple mutant phenotypes, overview Arabidopsis thaliana
metabolism MIPS catalyzes the rate-limiting step in de novo synthesis of myo-inositol Arabidopsis thaliana