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Literature summary for 5.5.1.4 extracted from
- Effects of valproate derivatives on human brain myo-inositol-1-phosphate (MIP) synthase activity and amphetamine-induced rearing (2007), Pharmacol. Rep., 59, 402-407.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | anticonvulsants valnoctamide and valrocemide drastically reduce enzyme activity in crude brain homogenate | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| valnoctamide | valproate derivative with anticonvulsant effect. Drastic inhibition of enzyme at 1 mM in crude brain homogenate, competitive | Homo sapiens |  |
| valrocemide | valproate derivative with anticonvulsant effect. Drastic inhibition of enzyme at 1 mM in crude brain homogenate | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.8 | - |
D-glucose 6-phosphate | pH 7.6, 37°C | Homo sapiens | |
| 3.4 | - |
D-glucose 6-phosphate | presence of 0.6 mM valnoctamide, pH 7.6, 37°C | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose 6-phosphate | - |
Homo sapiens | 1D-myo-inositol 3-phosphate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.18 | - |
valnoctamide | pH 7.6, 37°C | Homo sapiens | |
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